CAR T-cell therapy successfully reverses severe rheumatoid arthritis

Cell therapy substantially reduces severe rheumatoid arthritis in first clinical trial

Immunotherapies such as CAR T-cell therapy are used primarily to treat cancer. In the future, these patient-specific therapies, manufactured from patients' own immune cells, could also help cure autoimmune diseases. Six patients with particularly severe rheumatoid arthritis have now received this treatment at Charité—Universitätsmedizin Berlin. In the journal Nature Medicine, the researchers report the results from the world's first clinical tri…

CAR T-cell therapy successfully reverses severe rheumatoid arthritis

Immunotherapies such as CAR T-cell therapy are used primarily to treat cancer. In the future, these patient-specific therapies, manufactured from patients' own immune cells, could also help cure autoimmune diseases.

CAR T-Cell Therapy Puts Severe Rheumatoid Arthritis Into Remission in First Clinical Trial

Immunotherapies, like CAR T-cell therapy, are well known in the cancer field. But they can also be used to treat autoimmune disorders. Now, six patients with severe rheumatoid arthritis (RA) have received this treatment at Charité—Universitätsmedizin Berlin. The results from the world’s first clinical trial showed that disease activity decreased substantially in all participants. By the end of the observation period, three of the patients no lon…