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Caliway Biopharmaceuticals Presents Preclinical Research Supporting a Multi-Mechanism Approach to Weight Management at TMASO 2025

Combination of CBL-514 and tirzepatide reduced body weight by 21.8% and fat by over 40% in rats, outperforming incretin monotherapy, study shows.

  • On Dec. 15, 2025, Caliway Biopharmaceuticals presented preclinical research on CBL-514 combined with tirzepatide at the 25th Annual Congress of the Taiwan Medical Association for the Study of Obesity held at National Taiwan University Hospital, New Taipei City.
  • Researchers argued that targeting adipose tissue biology alongside incretin-based therapies could improve fat distribution and weight loss durability, the scientific community at TMASO 2025 emphasized multi-mechanism strategies beyond appetite control.
  • In the animal study design, researchers included an observation period after incretin withdrawal, showing the combination produced greater weight and fat reductions than tirzepatide alone in diet-induced obese rat models.
  • Caliway said the findings warrant further clinical investigation of adipocyte-targeted mechanisms to complement incretin pipelines, while Dr. Tzu-Jung Chou stressed more research is needed and company disclosures noted forward-looking statements and associated risks.
  • Caliway Biopharmaceuticals, TWSE: 6919, aims to lead innovation as TMASO 2025 experts from Taiwan, Japan and Korea highlight shifts toward durable weight loss and visceral fat reduction.
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Caliway Biopharmaceuticals Presents Preclinical Research Supporting a Multi-Mechanism Approach to Weight Management at TMASO 2025

Caliway Biopharmaceuticals' preclinical research was highlighted at the 25th Annual Congress of the Taiwan Medical Association for the Study of Obesity, held in conjunction with the 9th Japan-Korea-Taiwan Symposium on Obesity.The animal study explored CBL-514 in combination with a dual…

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PR Newswire broke the news in United States on Tuesday, December 16, 2025.
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