Patriots vs. Bills Predictions, Picks, and Best Bets for NFL Week 15

Patriots vs. Bills predictions, picks, and best bets for NFL Week 15

When the New England Patriots traveled into Highmark Stadium and knocked off the Buffalo Bills in a 23-20 Week 5 victory, it sent a warning call to the rest of the NFL that the Patriots are back. Now 10 weeks later the Bills are in town seeking revenge.

Bills/Patriots preview: Three storylines, two keys to the game, one X-Factor - Pickin' Splinters

Oct 5, 2025; Orchard Park, New York, USA; Buffalo Bills wide receiver Khalil Shakir (10) is tackled by New England Patriots cornerback Marcus Jones (25) in the fourth quarter at Highmark Stadium. (Photo: MARK KONEZNY) by TYLER HATHAWAY The Buffalo Bills and New England Patriots meet this Sunday in Foxborough for a game with major playoff implications. For Buffalo, it’s a chance to all but clinch a playoff spot and get on the fast-track to earn t…