Anti-CXCR3 Therapy Reduces Harmful Immune Cell Infiltration into the Brain
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The immune cells that damage the brain in Alzheimer's receive their instructions not in the brain, but in lymph nodes in the neck. American researchers discovered this in mice. When they blocked the mechanism, a large part (but not all) of the brain damage was prevented. Alzheimer's was long known as a disease of proteins that […] More science? Read the latest articles on Scientias.nl.
A study in mice found that blocking the CXCR3 receptor reduced the admission of T cells to the brain and was associated with less neurodegeneration in a tauopathy model. The results also included changes in the response of the microglya and improvements in some aspects of cognition, although they do not show that the strategy works in people.
Anti-CXCR3 Therapy Reduces Harmful Immune Cell Infiltration into the Brain
The immune system of the brain and body are distinct from one another, separated by the blood-brain barrier that lines blood vessels passing through the central nervous system. In health and youth, only small numbers of immune cells from the body pass in the brain, but this number increases considerably with advancing age and the presence of neurodegenerative disease. The blood-brain barrier leaks, and immune cells from the body finding their wa…
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