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Study Links Agent Orange Exposure to Rare Bone Marrow Cancers
Veterans exposed to Agent Orange develop myelodysplastic syndrome earlier with nearly double the risk of disease progression within two years, study finds.
- December 8, 2025 — the University of Miami team published a study in Blood showing Agent Orange exposure leads to earlier and more aggressive myelodysplastic syndrome, researchers reported Monday at the American Society of Hematology annual meeting, Orlando.
- Because prior studies lacked organized registries and diagnostic confirmation, veterans with suspected Agent Orange exposure struggled to qualify for service-connected benefits, and Sekeres called the effort `This study has been a personal quest`.
- Analyzing the MDS Natural History Study data, investigators found 130 participants exposed to Agent Orange had higher genetic mutation burden and were nearly twice as likely to progress within two years, a result Sekeres called `The progression finding was surprising`.
- For veterans, the study could change access to care by helping veterans with MDS obtain recognition, screening and coverage, while researchers plan follow-up analyses using national veteran databases.
- With about 2.6 million U.S. service members possibly exposed, MDS affects up to 20,000 Americans annually, and Black veterans were more than twice as likely to report exposure, with Sekeres warning `This toxin may have hit a particularly vulnerable population`.
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People exposed to Agent Orange face higher risk of developing myelodysplastic syndrome
A new national study shows for the first time that people exposed to Agent Orange face a higher risk of developing myelodysplastic syndrome (MDS), tend to develop it earlier, and often have more aggressive disease that is more likely to progress to acute myeloid leukemia.
·United States
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Agent Orange Linked To Rare Bone Marrow Cancers
Key Takeaways
Agent Orange exposure tied to earlier and more severe cases of myelodysplastic syndrome
A new national study shows for the first time that people exposed to Agent Orange face a higher risk of developing myelodysplastic syndrome (MDS), tend to develop it earlier, and often have more aggressive disease that is more likely to progress to acute myeloid leukemia.
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Total News Sources28
Leaning Left3Leaning Right2Center8Last UpdatedBias Distribution62% Center
Bias Distribution
- 62% of the sources are Center
62% Center
L 23%
C 62%
15%
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