Adding three simple amino acids boosts mRNA and CRISPR delivery

Adding three simple amino acids boosts mRNA and CRISPR delivery

Lipid nanoparticles, or LNPs, best known as the delivery vehicle for the COVID-19 mRNA vaccines received by billions of people, are now at the center of a much larger medical revolution.

Amino Acid Cocktail Supercharges LNP Delivery for mRNA and CRISPR Therapies

Lipid nanoparticles (LNPs) act as carriers for mRNA and CRISPR payloads across a wide range of therapeutic applications, from cancer to inflammatory and genetic diseases. The same delivery system used in COVID‑19 vaccines is now being adapted for other, more complex targets, but one challenge persists: LNPs transfer their cargo into cells far more readily in the lab than in the body. What makes in vivo delivery so much harder? A new study from B…