Success After a Century of Failures: Inside Moderna and Merck's Cancer Vaccine Breakthrough
The personalized mRNA shot, Intismeran, helped more than 1,000 patients stay cancer-free longer and lowered the risk of spread, the companies said.
- Merck and Moderna announced positive interim phase three clinical trial results for a personalized melanoma vaccine called Intismeran, which significantly extended cancer-free survival compared to existing immunotherapy alone.
- Scientists created the personalized vaccine by surgically collecting tumor samples, sequencing their DNA, and generating a treatment designed to train each patient's immune system to recognize and attack malignant cells.
- The trial enrolled more than 1,000 patients with high-risk melanoma, administering Intismeran alongside Keytruda to prevent tumor recurrence and limit disease spread to other organs.
- Cancer experts characterized the preliminary findings as encouraging, though the results remain unreviewed by independent researchers and require regulatory approval before becoming available through the NHS.
- Both companies are developing similar personalized vaccine candidates for lung, bladder, and kidney cancers, with comprehensive trial findings scheduled for presentation in October.
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17 Articles
Vaccine breakthrough stops cancer returning in trial
A personalized vaccine combined with an immunotherapy drug extended cancer-free survival in melanoma patients during a trial, though full results remain pending peer review and regulatory approval. The post Vaccine breakthrough stops cancer returning in trial appeared first on RocketNews.
Moderna Shares Drop 3.4% with $55 Billion Valuation Raising Questions About Cancer Vaccine Progress
CAMBRIDGE, Massachusetts, August 30, 2026, 16:12 (ET) Shares of Moderna dropped 3.35% on Friday, with trading volume reaching 178% of its average level.The company is still over 130% higher following its melanoma vaccine results.Analysts project cancer-vaccine revenues will top $1 billion by 2030 and reach $3 billion by 2035.Revenue in the second quarter reached $145…
"Intismeran Combines Immunotherapy and mRNA to Fight Skin Cancer"
An innovative treatment for skin cancer that merges immunotherapy with mRNA vaccine technology has shown promising outcomes in a late-phase trial, as per a joint announcement by pharmaceutical giants Merck and Moderna on Wednesday. The combined therapy, known as intismeran, outperformed standalone immunotherapy in curbing melanoma recurrence and preventing its spread in post-surgery melanoma patients. […] The post “Intismeran Combines Immunother…
Moderna and Merck’s personalized mRNA-based therapy has met key goals in a large-scale, phase III trial. The experimental treatment, combined with the immunotherapy Keytruda, reduced the risk of melanoma recurrence and distant spread. After more than a century of largely unsuccessful attempts, the first late-phase clinical trial of a therapeutic mRNA-based cancer vaccine has ended with a positive result. Moderna and […] The post Personalized can…
Pharmaceuticals Merck and Moderna claim to have revolutionary cancer therapy, a "therapeutic vaccine" that makes it difficult to come back...
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