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Rams Turn Attention to San Francisco 49ers on Short Week

Brock Purdy's toe soreness from a Week 1 injury casts doubt on his participation in a crucial NFC West Thursday night game, with the 49ers holding a 3-1 record so far.

  • The Los Angeles Rams are set to take on the San Francisco 49ers in an important Thursday night NFC West matchup, with both teams holding a 3-1 record to start the season.
  • The short week matchup follows the 49ers' 26-21 loss to the Jacksonville Jaguars, where quarterback Brock Purdy returned from a turf toe injury but felt soreness threatening his availability.
  • The Rams are unsure about the availability of left guard Steve Avila, who suffered an ankle sprain in Week 1 yet has resumed practicing recently, while the 49ers are managing injuries to wide receivers Ricky Pearsall and Jauan Jennings.
  • Rams coach Sean McVay highlighted the importance of concentrating on the fundamentals and making quick decisions when dealing with short preparation times. Regarding left guard Steve Avila’s availability for Thursday’s game, McVay responded cautiously, saying, "We'll see."
  • The Rams opened as 3.5-point favorites with the line jumping to 5.5, signaling expectations for a competitive game where both teams face challenges from injuries and quick turnarounds.
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49ers' Brock Purdy hopeful to play against Rams despite toe injury

Quarterback Brock Purdy is dealing with a toe injury that has sidelined him for two games this season.

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The San Francisco Standard broke the news in on Monday, September 29, 2025.
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